Beyond genotype: serotonin transporter epigenetic modification predicts human brain function
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چکیده
منابع مشابه
Serotonin Transporter Genotype (5-HTTLPR) Predicts Utilitarian Moral Judgments
BACKGROUND The psychological and neurobiological processes underlying moral judgment have been the focus of extensive recent research. Here we show that serotonin transporter (5-HTTLPR) genotype predicts responses to moral dilemmas featuring foreseen harm to an innocent. METHODOLOGY/PRINCIPAL FINDINGS Participants in this study judged the acceptability of actions that would unintentionally or...
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BACKGROUND The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be und...
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Disruption of the serotonin system has been implicated in anxiety and depression and a related genetic variation has been identified that may predispose individuals for these illnesses. The relationship of a functional variation of the serotonin transporter promoter gene (5-HTTLPR) on serotonin transporter binding using in vivo imaging techniques have yielded inconsistent findings when comparin...
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Implicit learning, the non-conscious acquisition of sequential and spatial environmental regularities, underlies skills such as language, social intuition, or detecting a target in a complex scene. We examined relationships between a variation of the dopamine transporter (DAT1) gene (SLC6A3), which influences dopamine transporter expression in the striatum, and two forms of implicit learning th...
متن کاملCentral serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.
OBJECTIVE A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2014
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.3778